Seminar: Leukocyte recruitment to the glomerulus

今天听了来自澳洲(MONASH)的Michael Kuligowski的presentation，讲的是白细胞（确切地说是（嗜）中性粒细胞）在肾小球发生炎症时是如何recruit的。他的研究主要集中在P-selectin的作用上。最后结论是，neutrophil不是直接在肾小球中急速流动的血流中rolling的。嗜中性粒细胞想要在内皮细胞上rolling，需要血小板的p-selectin。实验中用到了数种gene KO鼠，不过讲的比较快，没记住。另外还用了射线杀死骨髓造血干细胞，然后移植血小板，这点儿没太看明白——他们怎么排除其他血细胞的作用的呢？

Plos's interesting symbol

Is this the reason why more than two guys sharing the credit is generally not accepted?

到底Mantoux Test能不能测出是否接种过BCG呢？

也许俺的Mantoux Test皮试是白做了。中国的医疗纪录就是成问题啊。大家为了报销，用过的姓名就都是一箩筐。追查小时候生病时的处方和接种过的疫苗就更是Mission Impossible了。

至于这个问题，还是那个包治百病的理由——个体差异。

http://www.moh.govt.nz/moh.nsf/0/4760DF3580A6F5B5CC256C86006ED394/$File/2.Mantouxtesting.pdf
The effect of BCG vaccination on tuberculin reactivity

• The level of reactivity in a vaccinated person is variable, ranging between 0 and 15 mm. Reversion can occur (eg, the reaction wanes with time).
  

• A Mantoux reaction of > 15 mm induration should not be attributed to BCG vaccination.

• There is no relationship between the post-vaccination Mantoux result and protection against TB disease. Routine post-BCG vaccination tuberculin testing serves no purpose